Research
Databases, validation frameworks, standards, and research programs across microbiome science, metallomics, and translational medicine.
Microbiome Medicine
A clinician- and researcher-facing database formalizing disease-associated microbiome patterns through Major Microbial Associations (MMAs). Provides structured intervention guidance using the Microbial Shift and Realignment Process (MSRP) and dual-validation framework for Microbiome-Targeted Interventions (MBTIs).
Framework
A validated MBTI must meet three criteria: (1) Microbiome Signature Alignment, modulating the microbiome by increasing reduced taxa and decreasing elevated taxa in the condition's signature; (2) Clinical Efficacy, demonstrating measurable improvements in clinical outcomes; and (3) Dual Validation, whereby alignment simultaneously validates the intervention and confirms the microbiome signature's accuracy and clinical relevance.
Research Framework
Foundational work integrating trace metal analysis into microbiome research. Examines differential acquisition, utilization, and detoxification of trace elements (nickel, zinc, iron, cadmium, lead, aluminum) among taxa enriched in disease states. Introduces metallomics as a lens for pathogen virulence, microbial selection pressure, and nutrient-immune interactions.
Standards Development
Category-specific contaminant limits for food, supplements, and personal care products using ALARA-based principles and statistical risk matrices. Eight per-metal standards documents (Pb, As, Hg, Cd, Cr, Ni, Sn, Al) with anti-circumvention language, lot testing schedules, and governance policies.
Output Framework
A named recommendation class for discontinuing specific medical interventions, treatments, or standard practices based on emerging evidence suggesting they are ineffective, harmful, or counterproductive. Applied across microbiome and metallomics research to address translational delays.
Microbial Metallomics
Research into the role of nickel in microbial metallomic analyses related to endometriosis. Investigates how nickel-dependent pathogenic enzymes (urease, hydrogenase) interact with endometriosis microbiome signatures and contribute to disease persistence through metal-mediated virulence mechanisms.